Damien Oneknife was a deadly assassin living in Faerûn during the decades following the Time of Troubles (1358 DR). He was known for being opportunistic in battle, and he always tried to benefit from the assets of his enemies. One such battle saw him barely survive against a group of ghouls. In a bid to improve his chances during subsequent battles, he skinned one of them and had the hide magically enchanted to provide heightened protection against the ghoul's signature paralysation attack.

Damien was at one stage approached by an individual known as the Dockman and asked to assassinate the legendary drow warrior, Drizzt Do'Urden. At first he refused to perform the task, citing Drizzt's superior battle prowess as the reason. He was eventually persuaded otherwise, however, when the Dockman bribed him with an enchanted dagger called Risktaker which, unbeknownst to Damien, impaired his reasoning and judgment. Damien was killed by Drizzt's companions.

Damien is one of the pregenerated PCs in the game Neverwinter Nights: Hordes of the Underdark, though it wouldn't actually be consistent for him to appear in that story (as the protagonist was an inexperienced adventurer a short time before, and afterwards more powerful than even Drizzt).

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