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A cleric who used this spell was guaranteed that the target of the spell would never behave unethically toward them. Upon casting the spell, the caster determined the precise nature of ethics from which he would be guarded; including theft, murder, truth, or breaking a promise. For example, a target placed under a "theft" karma curse could never steal from the caster.
A karma curse could not be negated or removed by a remove curse spell. The number of potential targets for this spell rose with the cleric's skill. Only good-hearted clerics and priests could use this spell. Once cast, a karma curse was permanent.
This spell only required verbal and somatic components to cast.