In 1358 DR, during the Godswar, she helped Tiamat gain another avatar and witnessed the battle between Gilgeam and her goddess. However, afterward, Tiglath disappeared.
At one point, however, she resurfaced in Messemprar. After Mulhorand's invasion, Tiglath regained her position as high priestess and in 1374 DR she was the most powerful religious leader in free Unther.
Tiglath's goal was to destroy Gilgeam and his church and Tiamat was only a means to an end. She was filled with hatred and vengeance but was not an evil woman, a fact that concerned her goddess. After the Godswar, her new objective was to create a united church of Tiamat.